Abstract
In order to determine transference of cefminox (CMNX, MT-141) into the female genital organ tissues, the drug concentration in the pelvic dead space exudate was measured in cases undergone radical hysterectomy due to uterocervical cancer. For analysis of data the three-compartment model was used. When CMNX was given at a dose of 1g as an intravenous drip infusion taking 1 hour, the serum concentration of the cubital vein reached its peak of 89.53μg/ml at 1 hour after start of administration. In the pelvic dead space exudate the peak concentration of 39.84μg/ml was reached at 2.55 hours after administration and a concentration higher than 7μg/ml was still detected even at 12 hours. The area under the curve (AUC) for CMNX concentration in the pelvic dead space exudate was 295.63μg·hr/ml. These results suggest that CMNX achieves high concentration in the pelvic dead space exudate and that it is an antibiotic with clinical utility.
CMNX was used in the treatment of 6 cases of obstetrical and gynecological infections. The clinical results were excellent in 1 case, good in 2 cases and poor in 2 cases. In the remaining 1 case the results was unknown.
