The Japanese Journal of Antibiotics
Online ISSN : 2186-5477
Print ISSN : 0368-2781
ISSN-L : 0368-2781
SYNERGISTIC ACTIVITY OF ISEPAMICIN AND β-LACTAM ANTIBIOTICS AGAINST PSEUDOMONAS AERUGINOSA IN VITRO AND IN VIVO
YOSHINORI SHIRITANISHINYA YAMAJIAKIKO AOKIMIKIKO SAIGUSASHIGEYUKI YOKOIYAMASACHIKO GOTOAKIYOSHI TSUJI
Author information
JOURNAL FREE ACCESS

1988 Volume 41 Issue 11 Pages 1591-1599

Details
Abstract
Synergistic activities of isepamicin (ISP) and a β-lactam antibiotic such as piperacillin (PIPC)or cefotaxime (CTX) against Pseudomonas aeruginosa were demonstrated in vitro and in vivo.
In vitro synergistic activity was observed when ISP was used together PIPC or CTX.
The synergy observed in vitro was reproduced in vivo against experimental mouse infections, and a ISP-PIPC or a ISP-CTX combination showed significantly greater protective effects than individual antibiotics by themselves.
Content from these authors
© Japan Antibiotics Research Association
Previous article Next article
feedback
Top