SYNERGISTIC ACTIVITY OF ISEPAMICIN AND β-LACTAM ANTIBIOTICS AGAINST PSEUDOMONAS AERUGINOSA IN VITRO AND IN VIVO

Abstract

Synergistic activities of isepamicin (ISP) and a β-lactam antibiotic such as piperacillin (PIPC)or cefotaxime (CTX) against Pseudomonas aeruginosa were demonstrated in vitro and in vivo.
In vitro synergistic activity was observed when ISP was used together PIPC or CTX.
The synergy observed in vitro was reproduced in vivo against experimental mouse infections, and a ISP-PIPC or a ISP-CTX combination showed significantly greater protective effects than individual antibiotics by themselves.