血液疾患に併発した感染症におけるSulbactam/Cefoperazone・Amikacin併用療法

高島 輝行; 津田 昌一郎; 三澤 信一; 堀池 重夫; 葛山 由布子; 平川 浩一; 中井 浩之; 芹生 卓; 田中 新司; 西田 一弘; 谷脇 雅史; 加嶋 敬; 藤井 浩; 中川 均; 中井 哲郎; 大川原 康夫; 今西 仁; 西垣 光; 横田 昇平

doi:10.11553/antibiotics1968b.46.251

A COMBINED SULBACTAM/CEFOPERAZONE AND AMIKACIN THERAPY FOR THE TREATMENT OF INFECTIONS COMPLICATED WITH HEMATOLOGICAL DESEASES

TERUYUKI TAKASHIMA, SHOICHIRO TSUDA, SHINICHI MISAWA, SHIGEO HORIIKE, YUKO KUZUYAMA, KOUICHI HIRAKAWA, HIROYUKI NAKAI, TAKU SERIU, SHINJI TANAKA, KAZUHIRO NISHIDA, MASAFUMI TANIWAKI, KEI KASHIMA, HIROSHI FUJII, HITOSHI NAKAGAWA, TETSURO NAKAI, YASUO OHKAWARA, HITOSHI IMANISHI, HIKARI NISHIGAKI, SHOUHEI YOKOTA

Author information

TERUYUKI TAKASHIMA
The Third Department of Internal Medicine, Kyoto Prefectural University of Medicine
SHOICHIRO TSUDA
The Third Department of Internal Medicine, Kyoto Prefectural University of Medicine
SHINICHI MISAWA
The Third Department of Internal Medicine, Kyoto Prefectural University of Medicine
SHIGEO HORIIKE
The Third Department of Internal Medicine, Kyoto Prefectural University of Medicine
YUKO KUZUYAMA
The Third Department of Internal Medicine, Kyoto Prefectural University of Medicine
KOUICHI HIRAKAWA
The Third Department of Internal Medicine, Kyoto Prefectural University of Medicine
HIROYUKI NAKAI
The Third Department of Internal Medicine, Kyoto Prefectural University of Medicine
TAKU SERIU
The Third Department of Internal Medicine, Kyoto Prefectural University of Medicine
SHINJI TANAKA
The Third Department of Internal Medicine, Kyoto Prefectural University of Medicine
KAZUHIRO NISHIDA
The Third Department of Internal Medicine, Kyoto Prefectural University of Medicine
MASAFUMI TANIWAKI
The Third Department of Internal Medicine, Kyoto Prefectural University of Medicine
KEI KASHIMA
The Third Department of Internal Medicine, Kyoto Prefectural University of Medicine
HIROSHI FUJII
The Third Department of Internal Medicine, Kyoto First Red Cross Hospital
HITOSHI NAKAGAWA
The Third Department of Internal Medicine, Kyoto First Red Cross Hospital
TETSURO NAKAI
Internal Medicine, Aiseikai-Yamashina Hospital
YASUO OHKAWARA
Internal Medicine, Aiseikai-Yamashina Hospital
HITOSHI IMANISHI
Internal Medicine, Saiseikai Kyoto Hospital
HIKARI NISHIGAKI
Internal Medicine, Otsu Municipal Hospital
SHOUHEI YOKOTA
The First Department of Internal Medicine, Kyoto Prefectural Yosanoumi Hospital

JOURNAL FREE ACCESS

1993 Volume 46 Issue 3 Pages 251-258

DOI https://doi.org/10.11553/antibiotics1968b.46.251

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Abstract

Eightysix patients with infections associated with hematological disorders were treated with sulbactam/cefoperazone (SBT/CPZ) and amikacin (AMK). Among 71 evaluable cases, 30 cases had acute non-lymphocytic leukemia, 3 acute lymphoblastic leukemia, 25 malignant lymphoma, and 7 myelodysplastic syndrome as underlying diseases. Excellent responses were obtained in 33 cases (46.5%) and good responses in 14 cases (19.7%), with an overall efficacy rate of 66.2%. The efficacy rate among cases with suspected sepsis was 72.5%. This treatment was also effective in 69.2% of cases in which neutrophil counts were less than 500/μl through the course of administration. The eradication rate was 83.3% among 6 strains in which Gram-negative rods were detected. Side effects were minimum; skin rash in 1 case, slight elevation of APTT in 3 and slight elevation of total bilirubin in 1. Thus, this combination antibacterial chemotherapy is an effective and safe regimen for the treatment of severe infections in patients with hematological disorders.

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