The Japanese Journal of Antibiotics
Online ISSN : 2186-5477
Print ISSN : 0368-2781
ISSN-L : 0368-2781
CLINICAL STUDY OF FLUCONAZOLE-INJECTABLE AND-GRANULES IN PEDIATRIC PATIENTS
HIDETOSHI SEKI, AKIKO SENO, SINOBU SAKAZUME, KAZUKO SHINODA, NAOHISA SHINTANI, TAIZO WADA, HIDEO WADA, SHOICHI KOIZUMI, NOBORU TANIGUCHI, SEIKI HORITA, KUNIO OHTA, AKIHIRO KONNO, TETSURO OHKI, HITOSHI OOI, YUICHIRO MORIZIRI
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1994 Volume 47 Issue 3 Pages 289-295

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Abstract
In this study, we have investigated the clinical effectiveness of fluconazole (FLCZ) given intravenously or orally to pediatric patients with systemic fungal infections. FLCZ was administered intravenously to two patients with acute leukemia (multiple hepatosplenic candidiasis and aspergillo-sis) and orally to two mycosis complicated with neuroblastoma and aplastic anemia, respectively. Clinical efficacies were excellent and no side effects were observed in any patients.
Pharmacokinetic analysis in 6 neonates revealed that the plasma half-life is 37-41 hours after administration of single dose of intravenous infusion of 3mg/kg of FLCZ.
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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series B

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