The Journal of Antibiotics, Series A
Online ISSN : 2435-5135
Print ISSN : 0368-1173
ISSN-L : 0368-1173
Original Articles
Studies on Antiviral Antibiotics From Streptomyces. VII Phagostatin, A New Antiphage Antibiotic
Masa Hamada
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1957 Volume 10 Issue 2 Pages 74-79

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Abstract

In this laboratory, studies on antiphage agents produced by Streptomyces is carried out as a part of antiviral screening program concomitantly with the screening of the antibacterial substances. As already reported, phagomycin1) and phagocidin2),3) were isolated and investigated on the mode of actions. In the present paper, the author described a new antiphage substance, phagostatin, isolated from the mycelial mat of a strain of a streptomyces sp. (Our collection No. F-300). The antibiotic was obtained in a crystalline form, which was active against the growth of T3 and T7 phage without the inactivation of their free phage particles. It was also somewhat effective against organisms such as E. coli B, Sal. enteritidis, S. lutea, M. citreus and B. anthracis, but the antibacterial action was much lower than that against phage. The present report deals with the mycological characteristics of the strain, isolation and physicochemical properties of crystalline phagostatin. The results of the studies on the mode of action of the antibiotic will be described later.

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© 1957 JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
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