1958 Volume 11 Issue 1 Pages 21-25
In the previous paper1), mikamycin was reported to be closely related to streptogramin described by Cheney and others2) and the antibiotic No. 899 described by De Somer and Van Dijck3). Paper chromatographic studies made by the latter authors demonstrated three active substances in streptogramin and four active substances in the antibiotic No. 899. As described in previous papers1,4), mikamycin was a single antibiotic demonstrated by the paper chromatography, and properties of mikamycin suggested a closed relationship with the main active principles in streptogramin and the antibiotic No. 899.
Samples of streptogramin and the antibiotic No. 899 obtained through the courtesy of Dr. Charney and Dr. De Somer were comparatively studied with mikamycin. Results suggesting the identity of mikamycin with the main active substance of these two antibiotics are presented in this paper. Descriptions on streptogramin-producing strain were informed by Dr. Charney, and different points in characteristics of S. mitakaensis from S. graminofaciens are also described.