1960 Volume 13 Issue 4 Pages 260-264
In a previous paper of this series,1) the authors have reported that the adaptive oxidation of benzoic acid, niacin and malonic acid by avian tubercle bacilli were remarkably inhibited by a small amount of kanamycin (KM) and also the successive adaptation of benzoic acid was completely inhibited. Adaptive oxidation of these substrates by streptomycin-resistant strain was never inhibited even by a large amount of streptomycin (SM), while completely inhibited with a small amount of KM, and on the contrary, oxidation by KM-resistant strain was inhibited by SM, but KM had no effect on the reactions.
In this paper, the inhibitory effect of KM on the oxidation of C4-dicarboxylic acids (malate, fumarate, succinate) and diamine (putrescine) by avian tubercle bacilli is described.
