Septicemia Caused By Antibiotic-Resistant Staphylococci: Clinical Data and Therapeutic Considerations in 15 Cases

Abstract

The present interest in staphylococcal infections has been induced by increased incidence of staphylococci resistant to increasing number of antibiotics and their indiscriminate use. It is now an important hospital problem,^1),2),3),4) and septicemia due to antibiotic-resistant staphylococci have remained a serious therapeutic problem at the persent time. The mortality-rate of staphylococcal septicemia occurring in adults has still remained approximately from 50 to 70%.^6),10),29) It must be generally accepted that the therapeutic results were much different with the cases even if the antibiotics, to which the strain isolated from the patients was sensitive, were used in proper combination. The discrepancies between the sensitivity test in vitro and clinical effects were shown in several literatures.²⁴⁾

During the past 6 years there were 15 instances of staphylococcal septicemia including hospital-acquired cases at the First National Hospital in Tokyo. The present paper is concerned with a clinical analysis of this series with therapeutic considerations and the emergence of antibiotic-resistant strains of staphylococci isolated from the patients and healthy carriers in this country.