Antiprotozoal Antibiotics. III Preliminary Report on The Effect of Trypacidin on Experimental Toxoplasmosis

Abstract

After the discovery of trypacidin, which is an antibiotic with specific antiprotozoal activity^1,2), we studied the in vivo activity of this substance.

In the first preliminary experiments on the effect of trypacidin on the tissue culture of HeLa cells infected with Trypanosoma cruzi and Toxoplasma gondii, trypacidin exhibited a pronounced inhibitory effect on the intracellular forms of both parasites. The results of these experiments will be published elsewhere. This paper deals with the effect of trypacidin on experimental toxoplasmosis of mice. We are now also studying the effect of trypacidin on experimental Chagas’ disease and will publish the results later.