Danomycin, A New Antibiotic

Abstract

A new antimicrobial agent, danomycin, has been isolated from fermentation broths of a strain of Streptomyces named Streptomyces albaduncus nov. sp. The antibiotic is a watersoluble, iron-containing polypeptide having activity against Gram-positive bacteria both in vitro and in vivo. The biological and chemical studies revealed that the antibiotic is related to other iron-containing antibiotics such as grisein¹⁾, albomycin²⁾, LA-5352³⁾ or ferrimycin⁴⁾ in that they are water-soluble reddish colored substances having similar patterns of cross resistance.

This paper describes the producing organism, production, isolation and biologiical and physico-chemical properties of danomycin.