Effect of E. P. Hormone to the Inner Ear
Thrombosis of the Vascular System of the Inner Ear in E. P. Hormone-injected Guinea Pigs
1978 Volume 21 Issue 2 Pages 111-116
Details
1978 Volume 21 Issue 2 Pages 111-116
The purpose of this experiment is to examine pathologic change of the inner ear related to the disturbance of blood circulation due to contraceptives.
Twelve guinea pigs (6 males and 6 females) weighing approximately 300g were used. To each animal, 0.1ml of E. P. Hormone (contains 10mg of progesterone and 1mg of estradiol benzoate per 1ml) was injected intra-muscularly daily for 40 days. Pinna reflex was measured by audiometer, made for guinea pig, before and during the administration of the drug, and then the animals were sacrificed. The inner ear was examined histologically.
One of the 12 animals showed the pathologic changes of the vacular system of the inner ear. In this animal, hyaline thrombus like dense homogenous materials were frequently found in the capillary lumina of the stria vascularis and plexus cochlearis. These materials were distinctly different from blood clot in the vessels. The spiral organ and spiral ganglion did not indicate any pathologic changes. The tissue was rather well fixed, and postmortem change was minimum. In the vestibular organ, there was no thrombosis.
These thrombus like materials were most probably caused by an increase in coagulability of blood which may be induced by E. P. Hormone administration.
