In our previous report, we studied on genetic analysis of 20 patients in 11 families with Pendred's syndrome reported in Japan, and the results showed similar trends of the coefficient of consanguinity of the parents, sex-ratio, segregation ratio, frequency of abnormal gene and incidence of this disease between our study and those found in the literature of the world.
Moreover, we reviewed the literature, and the pathogenesis of deafness accompanied with goiter, pathohistological findings of the temporal bone, vestibular function, atypical cases of Pendred's syndrome and complications of this disease were also discussed.