AUDIOLOGY JAPAN
Online ISSN : 1883-7301
Print ISSN : 0303-8106
ISSN-L : 0303-8106
Effects of Intravenous Injection of Salicylate on the Cochlea of the Guinea Pigs
Masahiko KumagaiJun-Ichi MatsushimaChihiro HaradaYukio InuyamaTohru Ifukube
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1991 Volume 34 Issue 4 Pages 221-226

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Abstract

The purpose of this study was to determine action sites of Salicylate by recording the acoustically evoked action potentials (APs) and the electrically evoked compound action potentials (CAPs) through the round window membrane of the guinea pigs.
The acoustically evoked APs were recorded from a wire electrode placed on the round window membrane and the electrically evoked CAPs were recorded from a glass electrode inserted in the auditory nerve. Changes of amplitude in the APs and the CAPs were compared in guinea pigs before and after intravenous injections of 400mg/kg of salicylate.
The suppression ratio of acoustically evoked APs at low sound intensity was significantlly greater than that of electrically evoked CAPs at low and high current levels.
The findings of this study indicate that salicylate decreased the excitability of both the cochlear nerve fibers and the hair cells.

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