Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Food & Nutrition Regular Papers
Polysaccharides from Agaricus blazei Stimulate Lymphocyte T-Cell Subsets in Mice
Masashi MIZUNOMikio MORIMOTOKen-ichiro MINATOHironobu TSUCHIDA
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1998 年 62 巻 3 号 p. 434-437

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  Subset analysis of splenic lymphocytes using flow cytometry showed that the percentages of Thy1.2-(pan T-cells), L3T4-(CD4, helper T-cells), and Lyt2-(CD8, cytotoxic T-cells) positive cell populations were significantly increased in mice orally administered a hot water-soluble fraction from Agaricus blazei as compared with mice treated only with saline. 13C-NMR data indicates that the main component in the active polysaccharide is the complex of α-1,6- and α-1,4-glucan, which had already been shown to have anti-tumor activity against Sarcoma 180. It seems that the polysaccharide from Agaricus blazei may be an effective prophylactic, protecting humans against cancer by stimulating lymphocytes such as cytotoxic T-cells.

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© 1998 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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