Apoptosis Induced by the Flavonoid from Lemon Fruit (Citrus limon BURM. f.) and Its Metabolites in HL-60 Cells

Shin OGATA; Yoshiaki MIYAKE; Kanefumi YAMAMOTO; Katsuzumi OKUMURA; Hiroshi TAGUCHI

doi:10.1271/bbb.64.1075

Food & Nutrition Science Notes

Apoptosis Induced by the Flavonoid from Lemon Fruit (Citrus limon BURM. f.) and Its Metabolites in HL-60 Cells

Shin OGATA, Yoshiaki MIYAKE, Kanefumi YAMAMOTO, Katsuzumi OKUMURA, Hiroshi TAGUCHI

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Keywords: apoptosis, lemon fruit, flavonoids, eriodictyol, HL-60

JOURNAL FREE ACCESS

2000 Volume 64 Issue 5 Pages 1075-1078

DOI https://doi.org/10.1271/bbb.64.1075

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Abstract

The flavonoid from lemon fruit (Citrus limon BURM. f.) and its metabolites, particularly eriodictyol, 3,4-dihydroxyhydrocinnamic acid, and phloroglucinol had the function of DNA fragmentation in HL-60 cells when analyzed by flow cytometry. An apoptotic DNA ladder and chromatin condensation were observed in HL-60 cells when treated with these compounds. The caspase inhibitor prevented DNA fragmentation. These compounds are anticipated to be useful for medical purposes.

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