Synthesis of Corollosporine, an Antibacterial Metabolite of the Marine Fungus Corollospora maritima

Abstract

Corollosporine [(±)-3-hexyl-3,7-dihydroxy-1(3H)-isobenzofuran-1-one], an antibacterial metabolite of the marine fungus, Corollospora martima, was synthesized by four different routes from 3-hydroxyphthalic anhydride or 2-methoxybenzoic acid as the starting material to verify its proposed structure.