Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Organic Chemistry
Chemical Synthesis and Biological Activity of The Gelatinase Biosynthesis-Activating Pheromone of Enterococcus faecalis and Its Analogs
Jiro NAKAYAMAYong CAOTakaaki HORIIShohei SAKUDAHiromichi NAGASAWA
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JOURNALS FREE ACCESS

2001 Volume 65 Issue 10 Pages 2322-2325

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Abstract

An 11-residue peptide lactone, termed the gelatinase biosynthesis-activating pheromone (GBAP), triggers the production of the pathogenicity-related extracellular proteases, gelatinase and serine protease, in Enterococcus faecalis. In this study, we synthesized GBAP and its analogs and examined their gelatinase biosynthesis-inducing activity. This study on the structure-activity relationship shows that a lactone ring was indispensable for the activity.

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© 2001 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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