Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Food & Nutrition Science
Antimutagenic Acitivity against Trp-P-1 of the Edible Thai Plant, Oroxylum indicum Vent.
Kazuhiko NAKAHARAMayumi ONISHI-KAMEYAMAHiroshi ONOMitsuru YOSHIDAGassinee TRAKOONTIVAKORN
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2001 Volume 65 Issue 10 Pages 2358-2360

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Abstract

A methanolic extract of Oroxylum indicum strongly inhibited the mutagenicity of Trp-P-1 in an Ames test. The major antimutagenic constituent was identified as baicalein with an IC50 value of 2.78±0.15 μM. The potent antimutagenicity of the extract was correlated with the high content (3.95±0.43%, dry weight) of baicalein. Baicalein acted as a desmutagen since it inhibited the N-hydroxylation of Trp-P-2.

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© 2001 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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