Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Review
Super-channel in Bacteria: Function and Structure of a Macromolecule Import System Mediated by a Pit-dependent ABC Transporter
Wataru HASHIMOTOKeiko MOMMAYumiko MISHIMABunzo MIKAMIKousaku MURATA
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JOURNALS FREE ACCESS

2001 Volume 65 Issue 9 Pages 1949-1956

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Abstract

In a soil isolate, Sphingomonas sp. A1, the transport of a macromolecule (alginate: 27 kDa) is mediated by a pit-dependent ATP-binding cassette (ABC) transporter. The transporter is different from other ABC transporters so far analyzed in that its function is dependent on the pit, a mouth-like organ formed on the cell surface only when the cells are compelled to assimilate macromolecules, and in that it allows direct import of macromolecules into cells. The ABC transporter coupled with the pit, which functions as a funnel and/or concentrator of macromolecules to be imported, was designated as the “Super-channel”, and in this review, we discuss the three-dimensional structure and specific function of the “Super-channel” for macromolecule import found for the first time in a bacterium.

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© 2001 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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