Total Synthesis of (±)-syn-Copalol

Abstract

  The labdane diterpene derivative, syn-copalol [(+)-5] is the alcohol part of syn-copalyl diphosphate [(+)-4]. In this paper, racemic (±)-5 was synthesized from a known racemic lactone in 8 steps. The current and our previous syntheses provide all four copalol derivatives [(+)-3, (−)-3 and (±)-5] which are required for the biosynthetic study of polycyclic diterpenes.