Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Biochemistry & Molecular Biology Notes
Activin A Induces Phosphorylation of Smad2 but Not Complex Formation of Smad2 with Smad4 in Human Colon Cancer Cell Line HT-29
Pimara PHOLNUKULKITKei SONOYAMAJun KAWABATA
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JOURNAL FREE ACCESS

2003 Volume 67 Issue 9 Pages 2042-2044

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Abstract

  Western blotting coupled with immunoprecipitation showed that activin A treatment induced phosphorylation of Smad2 but not complex formation of Smad2/4 in human colon cancer-derived HT-29 cells. Because HT-29 cells expressed neither Smad4 mRNA nor Smad4 protein, it is suggested that deletion of Smad4 leads to a defect of formation of Smad2/4 complex upon activin A stimulation in HT-29 cells.

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© 2003 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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