Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Analytical Chemistry Regular Paper
Fragrances in Oolong Tea That Enhance the Response of GABAA Receptors
Sheikh Julfikar HOSSAINHitoshi AOSHIMAHirofumi KODAYoshinobu KISO
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2004 Volume 68 Issue 9 Pages 1842-1848


We electrophysiologically investigated the effect of some fragrant compounds in oolong tea on the response of ionotropic γ-aminobutyric acid (GABA) receptors (GABAA receptors) which were expressed in Xenopus oocytes. Of the tested fragrances in oolong tea, cis-jasmone, jasmine lactone, linalool oxide and methyl jasmonate significantly potentiated the response. Among these, cis-jasmone and methyl jasmonate potently potentiated the response, having a respective dissociation constant of the compound (Kp) and maximum potentiation (Vm) of 0.49 mM and 322% for cis-jasmone, and 0.84 mM and 450% for methyl jasmonate. Inhalation of 0.1% cis-jasmone or methyl jasmonate significantly increased the sleeping time of mice induced by pentobarbital, suggesting that these fragrant compounds were absorbed by the brain and thereby potentiated the GABAA receptor response. Both of these compounds may therefore have a tranquillizing effect on the brain.

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© 2004 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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