Uncoupling of Longevity and Paraquat Resistance in Mutants of the Nematode Caenorhabditis elegans

Michihiko FUJII; Nanae TANAKA; Kensuke MIKI; Mohammad Nazir HOSSAIN; Morio ENDOH; Dai AYUSAWA

doi:10.1271/bbb.69.2015

Biochemistry & Molecular Biology Notes

Uncoupling of Longevity and Paraquat Resistance in Mutants of the Nematode Caenorhabditis elegans

Michihiko FUJII, Nanae TANAKA, Kensuke MIKI, Mohammad Nazir HOSSAIN, Morio ENDOH, Dai AYUSAWA

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Keywords: Caenorhabditis elegans, oxidative stress, paraquat, aging, Dyf

JOURNAL FREE ACCESS

2005 Volume 69 Issue 10 Pages 2015-2018

DOI https://doi.org/10.1271/bbb.69.2015

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Abstract

To analyze the relationship between resistance to oxidative stress and longevity, we isolated three novel paraquat-resistant mutants, mev-5, mev-6, and mev-7, from the nematode Caenorhabditis elegans. They all showed the Dyf (defective in dye filling) phenotype, but not always resistance to heat or UV. Life-span extension was observed only in the mev-5 mutant at 26 °C. These results indicate that longevity is uncoupled with the phenotype of paraquat resistance.

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