Inhibition of Preadipocyte Differentiation by Germacranolides from Calea urticifolia in 3T3-L1 Cells

Nobuyasu MATSUURA; Masashi YAMADA; Hiroto SUZUKI; Naoko HASEGAWA; Chihiro KUROSAKA; Makoto UBUKATA; Toshiyuki TANAKA; Munekazu IINUMA

doi:10.1271/bbb.69.2470

Food & Nutrition Science Communications

Inhibition of Preadipocyte Differentiation by Germacranolides from Calea urticifolia in 3T3-L1 Cells

Nobuyasu MATSUURA, Masashi YAMADA, Hiroto SUZUKI, Naoko HASEGAWA, Chihiro KUROSAKA, Makoto UBUKATA, Toshiyuki TANAKA, Munekazu IINUMA

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Keywords: germacranolide, 3T3-L1, differentiation, inhibitor, Calea urticifolia

JOURNAL FREE ACCESS

2005 Volume 69 Issue 12 Pages 2470-2474

DOI https://doi.org/10.1271/bbb.69.2470

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Abstract

The effects of germacranolides isolated from Calea urticifolia on adipocytic differentiation of 3T3-L1 cells were examined. These germacranolides inhibited adipogenesis at a concentration of 1.25–5 μM. But no inhibitory activity against cell proliferation and no nonspecific binding activity to protein were observed. These results indicate that these germacranolides are the specific inhibitors of preadipocyte differentiation.

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