Antihyperglycemic Activity of Herb Extracts on Streptozotocin-Induced Diabetic Rats

Chang Hwa JUNG; Song ZHOU; Guo Xun DING; Ji Hye KIM; Myung Hee HONG; Yong-Cheol SHIN; Gyung Jun KIM; Seong-Gyu KO

doi:10.1271/bbb.60238

Food & Nutrition Science Notes

Antihyperglycemic Activity of Herb Extracts on Streptozotocin-Induced Diabetic Rats

Chang Hwa JUNG, Song ZHOU, Guo Xun DING, Ji Hye KIM, Myung Hee HONG, Yong-Cheol SHIN, Gyung Jun KIM, Seong-Gyu KO

Author information

Chang Hwa JUNG
Laboratory of Clinical Biology and Pharmacogenomics, College of Oriental Medicine, Kyunghee University
Institute of Oriental Medicine, Kyunghee University
Song ZHOU
Laboratory of Clinical Biology and Pharmacogenomics, College of Oriental Medicine, Kyunghee University
Guo Xun DING
Laboratory of Clinical Biology and Pharmacogenomics, College of Oriental Medicine, Kyunghee University
Ji Hye KIM
Laboratory of Clinical Biology and Pharmacogenomics, College of Oriental Medicine, Kyunghee University
Institute of Oriental Medicine, Kyunghee University
Myung Hee HONG
Laboratory of Clinical Biology and Pharmacogenomics, College of Oriental Medicine, Kyunghee University
Institute of Oriental Medicine, Kyunghee University
Yong-Cheol SHIN
Laboratory of Clinical Biology and Pharmacogenomics, College of Oriental Medicine, Kyunghee University
Institute of Oriental Medicine, Kyunghee University
Gyung Jun KIM
Department of Ophthalmology and Otorhinolaryngology, College of Oriental Medicine, Kyungwon University
Seong-Gyu KO
Laboratory of Clinical Biology and Pharmacogenomics, College of Oriental Medicine, Kyunghee University
Institute of Oriental Medicine, Kyunghee University

Keywords: herb extracts, Rhus verniciflua, blood glucose, thiobarbituric acid reactive substances, diabetic rats

JOURNAL FREE ACCESS

2006 Volume 70 Issue 10 Pages 2556-2559

DOI https://doi.org/10.1271/bbb.60238

View "Advance Publication" version (October 7, 2006).

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Abstract

We investigated the effects of herb extracts, Rhus verniciflua, Agrimonia pilosa, Sophora japonica, and Paeonia suffruticosa, on the lowering of blood glucose levels and thiobarbituric acid reactive substances (TBARS) in streptozotocin (STZ)-induced diabetic rats. After 4 weeks, oral administration of Rhus verniciflua extract (50 mg/kg) exhibited a significant decrease in blood glucose levels in diabetic rats (P<0.05). Blood TBARS concentrations, the products of glucose oxidation in blood, were also lowered by Rhus verniciflua extract supplementation. In addition, Sophora japonica and Paeonia suffruticosa extracts significantly reduced TBARS levels versus diabetic controls. Serum concentrations of liver-function marker enzymes, GOT and GPT, were also restored by Rhus verniciflua (50 mg/kg) supplementation in diabetic rats.

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