Comparisons of Potentials for L-Lysine Production among Different Corynebacterium glutamicum Strains

Abstract

Corynebacterium glutamicum is an industrially important organism that is most widely used for the production of various amino acids. A defined L-lysine-producing mutant was generated by introduction of the lysC mutation (T311I) into each of six representative C. glutamicum strains. The resulting six isogenic mutants were compared for L-lysine production under traditional 30 °C conditions and industrially more advantageous 40 °C conditions. It was found that there were significant differences in yield and productivity, especially at 40 °C. These results indicate the diversity among C. glutamicum strains in fermentative characters, as well as the importance of selecting a strain with industrially best performance.