Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Biochemistry & Molecular Biology Notes
Down-Regulation of mdr1b mRNA Expression in the Kidneys of Mice Following Maternal Exposure to Tributyltin Chloride
Kazuo KOBAYASHI-HATTORITakahiro WATANABEKimiko KIMURAYoshiko SUGITA-KONISHI
Author information
JOURNAL FREE ACCESS

2006 Volume 70 Issue 5 Pages 1242-1245

Details
Abstract

We investigated the change in renal mdr1b mRNA expression in offspring exposed to tributyltin chloride (TBTC) via the placenta and lactation or via lactation, using the real-time reverse transcription-polymerase chain reaction. Pregnant ICR mice were given water containing TBTC (0, 15, and 50 μg/ml) ad libitum from the start of pregnancy to weaning or from parturition to weaning. Exposure via the placenta and lactation significantly reduced the renal mdr1b level in offspring. Exposure to TBTC through the mother might impair the exclusion system of toxic compounds in offspring.

Content from these authors

This article cannot obtain the latest cited-by information.

© 2006 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
Previous article Next article
feedback
Top