2009 Volume 73 Issue 2 Pages 457-460
The influence of lactic acid bacteria (LAB) on CD4+Foxp3+ cells has not been investigated, although it has been reported that CD4+Foxp3+ cells might be involved in the inhibition of allergic symptoms. Hence we examined the effect of orally administered LAB on CD4+Foxp3+ generation. Oral administration of Lactobacillus plantarum NRIC0380 significantly inhibited antigen-specific IgE production and enhanced the Th1 response, as some other strains reported in previous studies. The ratio of CD4+CD25+Foxp3+ cells in whole CD4+ cells was significantly higher in both Peyer’s patch and the spleen of mice that had been fed with LAB than in the control mice.
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