Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Food & Nutrition Science Communication
Oral Administration of Lactobacillus plantarum NRIC0380 Suppresses IgE Production and Induces CD4+CD25+Foxp3+ Cells in Vivo
Mai ENOMOTOSayo NOGUCHIMakoto HATTORIHisashi SUGIYAMAYasuyuki SUZUKIAkihiro HANAOKASanae OKADATadashi YOSHIDA
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2009 Volume 73 Issue 2 Pages 457-460

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Abstract

The influence of lactic acid bacteria (LAB) on CD4+Foxp3+ cells has not been investigated, although it has been reported that CD4+Foxp3+ cells might be involved in the inhibition of allergic symptoms. Hence we examined the effect of orally administered LAB on CD4+Foxp3+ generation. Oral administration of Lactobacillus plantarum NRIC0380 significantly inhibited antigen-specific IgE production and enhanced the Th1 response, as some other strains reported in previous studies. The ratio of CD4+CD25+Foxp3+ cells in whole CD4+ cells was significantly higher in both Peyer’s patch and the spleen of mice that had been fed with LAB than in the control mice.

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© 2009 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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