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Bioscience, Biotechnology, and Biochemistry
Vol. 73 (2009) No. 2 P 443-446



Biochemistry & Molecular Biology Notes

Rrs1 has an essential role in 60S ribosomal subunit assembly in Saccharomyces cerevisiae. We isolated a temperature-sensitive kcs1 mutant that suppresses the cold sensitivity of rrs1-1. The kcs1 allele, resulting in truncation of inositol 6 phosphate kinase domain, and kcs1 disruption suppress a defect of rrs1-1 in 60S ribosomal subunit assembly. These results suggest that inositol polyphosphate metabolism affects ribosome biogenesis in yeast.

Copyright © 2009 by Japan Society for Bioscience, Biotechnology, and Agrochemistry

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