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Bioscience, Biotechnology, and Biochemistry
Vol. 74 (2010) No. 1 P 195-198



Biochemistry & Molecular Biology Notes

DNA replication without telomerase leads to telomere shortening and induces replicative senescence. We found that in a telomerase-deficient budding yeast mutant, the volume of each telomere-shortened cell increased as its growth capacity decreased, and that this process was associated with changes in vacuolar morphology. Senescence-induced cell expansion required Mec1, a DNA damage-responsive kinase, but not vacuolar SNARE Vam3.

Copyright © 2010 by Japan Society for Bioscience, Biotechnology, and Agrochemistry

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