Two Distinct Epitopes on the Ovalbumin 323-339 Peptide Differentiating CD4+T Cells into the Th2 or Th1 Phenotype

Haruyo NAKAJIMA-ADACHI; Emiko KOIKE; Mamoru TOTSUKA; Erika HIRAIDE; Yoshio WAKATSUKI; Hiroshi KIYONO; Satoshi HACHIMURA

doi:10.1271/bbb.120349

Food & Nutrition Science Notes

Two Distinct Epitopes on the Ovalbumin 323-339 Peptide Differentiating CD4⁺T Cells into the Th2 or Th1 Phenotype

Haruyo NAKAJIMA-ADACHI, Emiko KOIKE, Mamoru TOTSUKA, Erika HIRAIDE, Yoshio WAKATSUKI, Hiroshi KIYONO, Satoshi HACHIMURA

Author information

Haruyo NAKAJIMA-ADACHI
Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Science, The University of Tokyo
Emiko KOIKE
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Science, The University of Tokyo
Mamoru TOTSUKA
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Science, The University of Tokyo
Erika HIRAIDE
Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Science, The University of Tokyo
Yoshio WAKATSUKI
Department of Clinical Bio-regulatory Science, Kyoto University Graduate School of Medicine
Hiroshi KIYONO
Department of Mucosal Immunology, Institute of Medical Science, The University of Tokyo
Satoshi HACHIMURA
Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Science, The University of Tokyo

Keywords: OVA323-339 amino acid residue, food allergy, tolerance, oral immunotherapy, epitope

JOURNAL FREE ACCESS

2012 Volume 76 Issue 10 Pages 1979-1981

DOI https://doi.org/10.1271/bbb.120349

View "Advance Publication" version (October 7, 2012).

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Abstract

The epitopes for OVA323-339-specific CD4⁺T cells from OVA23-3 food allergy model and DO11.10 tolerant induction model mice were analyzed. We found that OVA23-3 CD4⁺T cells recognized the N-terminal region, showing strong proliferation and the Th2-phenotype, and that DO11.10 CD4⁺T cells recognized the C-terminal region, showing milder proliferation and a Th1-skewed response. These differences may regulate the responses of those mice to OVA-feeding, inflammation and tolerance.

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