Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Food & Nutrition Science Notes
Improved High-Fat Diet-Induced Glucose Intolerance by an Oral Administration of Phytosphingosine
Itsuo MURAKAMISusumu MITSUTAKENaoyuki KOBAYASHIJunko MATSUDAAkemi SUZUKITatsuro SHIGYOYasuyuki IGARASHI
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2013 Volume 77 Issue 1 Pages 194-197

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Abstract

We have previously reported that phytoceramide and phytosphingosine (PHS) stimulated the transcriptional activity of peroxisome proliferator-activated receptor γ (PPARγ) in cells. PPARγ is a therapeutic target for type 2 diabetes. We found in this study that an oral administration of PHS improved diet-induced glucose intolerance in mice. Since PHS is highly expressed in yeast, PHS in fermented foods may improve diabetes.

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© 2013 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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