Cytotoxic Activity of New Phenolic Compounds from Vietnamese Caesalpinia sappan

Tran Manh HUNG; Nguyen Xuan HAI; Nguyen Trung NHAN; Ton That QUANG; Tran Le QUAN; To Dao CUONG; Nguyen Hai DANG; Nguyen Tien DAT

doi:10.1271/bbb.130493

Organic Chemistry Regular Paper

Cytotoxic Activity of New Phenolic Compounds from Vietnamese Caesalpinia sappan

Tran Manh HUNG, Nguyen Xuan HAI, Nguyen Trung NHAN, Ton That QUANG, Tran Le QUAN, To Dao CUONG, Nguyen Hai DANG, Nguyen Tien DAT

Author information

Tran Manh HUNG
Faculty of Chemistry, University of Science, Vietnam National University
College of Pharmacy, Catholic University of Daegu
Nguyen Xuan HAI
Faculty of Chemistry, University of Science, Vietnam National University
Nguyen Trung NHAN
Faculty of Chemistry, University of Science, Vietnam National University
Ton That QUANG
Faculty of Chemistry, University of Science, Vietnam National University
Tran Le QUAN
Faculty of Chemistry, University of Science, Vietnam National University
To Dao CUONG
College of Pharmacy, Catholic University of Daegu
Nguyen Hai DANG
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
Nguyen Tien DAT
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)

Keywords: Caesalpinia sappan, Leguminosae, caesalpiniaphenols, HL-60, apoptosis

JOURNAL FREE ACCESS

2013 Volume 77 Issue 12 Pages 2378-2382

DOI https://doi.org/10.1271/bbb.130493

View "Advance Publication" version (December 7, 2013).

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Abstract

Two new phenolic compounds, caesalpiniaphenols G–H (1 and 2), were isolated from Vietnamese Caesalpinia sappan heartwood. The chemical structures were established mainly by extensive spectroscopic studies and chemical evidence. Compounds 1 and 2 showed potent inhibitory activity against HL-60 cancer cell lines with respective IC₅₀ values of 16.7 and 22.5 µg/mL. Treating HL-60 cells with various concentrations of 1 resulted in growth inhibition and the induction of apoptosis.

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