Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Biochemistry & Molecular Biology Notes
Cytotoxic Effects of Secosterols and Their Derivatives on Several Cultured Cells
Susumu TOMONOYukari YASUENoriyuki MIYOSHIHiroshi OHSHIMA
Author information
JOURNAL FREE ACCESS

2013 Volume 77 Issue 3 Pages 651-653

Details
Abstract

The cytotoxic effects of various oxysterols on several culture cells were examined. Ozonolysis products of cholesterol, secosterols (3β-hydroxy-5-oxo-5,6-secocholestan-6-al) and its aldolization product (3β-hydroxy-5β-hydroxy-B-norcholestane-6β-carboxaldehyde) and their keto alcohol and acid derivatives, were found to have potent cytotoxic activities, as compared with major endogenous oxysterols such as 5β,6β-epoxycholesterol, 7β-hydroxycholesterol, 7-ketocholesterol, and 25-hydroxycholesterol. Secosterols might play important roles in tissue damage and inflammation-associated diseases.

Content from these authors

This article cannot obtain the latest cited-by information.

© 2013 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
Previous article Next article
feedback
Top