Specific 5-Hydroxylation of Piperlongumine by Beauveria bassiana ATCC 7159

Jiachen ZI; S. Gabrielle GLADSTONE; Jixun ZHAN

doi:10.1271/bbb.120223

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Specific 5-Hydroxylation of Piperlongumine by Beauveria bassiana ATCC 7159

Jiachen ZI, S. Gabrielle GLADSTONE, Jixun ZHAN

著者情報

キーワード: anti-cancer, Beauveria bassiana ATCC 7159, biotransformation, hydroxylation, piperlongumine

ジャーナルフリー早期公開

論文ID: 120223

DOI https://doi.org/10.1271/bbb.120223

この記事には本公開記事があります。

The final version of this article is now available: Vol. 76 (2012) , No. 8 p.1565

詳細

抄録

A new hydroxylated derivative was efficiently prepared by transforming the natural anti-cancer product, piperlongumine, with Beauveria bassiana ATCC 7159. Its structure was determined to be 5-hydroxylpiperlongumine on the basis of the spectroscopic data. The absolute configuration at C-5 was established as R by Mosher's method.

責任著者(Corresponding author)

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