Agricultural and Biological Chemistry
Online ISSN : 1881-1280
Print ISSN : 0002-1369
ISSN-L : 0002-1369
Phosphorylation of Streptomycin at C6-OH of Streptidine Moiety by an Intracellular Enzyme of Streptomyces griseus
Osamu NIMIGaku ITOSatoru SUEDARyosaku NOMI
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1971 年 35 巻 6 号 p. 848-855

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In streptomycin-producing Streptomyces griseus HUT 6037, an enzyme which phosphorylated streptomycin appeared in old mycelium at stationary to autolyzing stage. This enzyme phosphorylated streptomycin with equimolar ATP at C6-OH in the streptidine moiety. This phosphomonoester of streptomycin was identified with the phosphorylated streptomycin (referred to as L compound) which was previously reported to accumulate in the culture broth when the pH was controlled below neutral.
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© Japan Society for Bioscience, Biotechnology, and Agrochemistry
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