Agricultural and Biological Chemistry
Online ISSN : 1881-1280
Print ISSN : 0002-1369
ISSN-L : 0002-1369
Biochemical and Biological Studies on Dopastin, an Inhibitor of Dopamine β-Hydroxylase
Hironobu IINUMAMeiki MATSUZAKIToshiharu NAGATSUTomio TAKEUCHIHamao UMEZAWA
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1974 Volume 38 Issue 11 Pages 2107-2111

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Abstract

Dopastin produced by a pseudomonas is a potent inhibitor of dopamine β-hydroxylase. Kinetic studies with the purified enzyme indicated that inhibition by dopastin was of the uncompetitive type to the substrate and of the competitive to the cofactor, ascorbic acid. The nitrosohydroxylamino group of dopastin was found to be essential in inhibition of dopamine β-hydroxylase. Both racemic and natural dopastins showed the same activity. Dopastin showed significant hypotensive effect to spontaneously hypertensive rats and phytotoxicity to barley germination.

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