抄録
A novel aspartate aminotransferase inhibitor named gostatin was isolated as crystals from the culture filtrate of Streptomyces sumanensis NK-23. The structure has been established to be 5-amino-2-carboxy-4-oxo- 1, 4, 5, 6-tetrahydropyridine-3-acetic acid by X-ray crystallographic analysis (K. Ibata et al., manuscript in preparation). The results of chemical and instrumental analyses of the inhibitor are described in this paper.
Gostatin showed time-dependent inhibitory action against aspartate aminotransferases and alanine aminotransferase. Both pyridoxal phosphate- and pyridoxamine phosphate-linked enzymes were sensitive to the inhibitor.
