Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Preferential Suppression of Delayed-type Hypersensitivity by L-156, 602, a C5a Receptor Antagonist
Ryohei F. TSUJIMasakazu URAMOTOHiroyuki KOSHINONoriko M. TSUJIJunji MAGAEKazuo NAGAIMakari YAMASAKI
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1992 Volume 56 Issue 10 Pages 1686-1689

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Abstract

In the course of our screening for in vivo immunomodulating substances in which sheep red blood cells (SRBC) and heat-killed Brucella abortus cells (thymus dependent and independent antigens, respectively) for antibody production assays, and trinitrobenzene sulfonic acid (TNBS) for delayed-type hypersensitivity (DTH) assay were adopted as antigens, we detected a DTH-specific suppressive activity. The producing organism was isolated from a soil sample collected in Ushiku City, Ibaraki, Japan and identified with Streptomyces sp. A1502 (FERM P-12448). The active component was identified with L-156, 602, a C5a receptor antagonist. L-156, 602 suppressed both TNBS-induced and TNP-SRBC-induced DTH while it enhanced antibody production against SRBC, Brucella abortus, and TNP-SRBC. L-156, 602 significantly suppressed DTH induced by direct injection of type 1 helper T cells and its relevant antigen into hindfootpads, indicating that the efferent phase of DTH was affected by L-156, 602. The results demonstrated that L-156, 602 preferentially suppressed the DTH response.

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