Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Degradation of Streptomyces Metalloprotease Inhibitor (SMPI) by Neutral Protease from Bacillus subtilis var. amylosacchariticus
Daisuke TSURUYasuyuki FUJITAShin-ya MORIKAWAKiyoshi ITOTadashi YOSHIMOTO
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1992 Volume 56 Issue 8 Pages 1275-1278

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Abstract

The zinc-containing neutral endopeptidase (neutral protease : BANP) from Bacillus subtilis var. amlosacchariticus was inhibited by the proteinaceous metalloprotease inhibitor isolated from Streptomyces nigrescens (SMPI). The degree of inhibition was, however, significantly less than that for thermolysin (TLN). During incubation of BANP with SMPI, the inhibitor was proteolytically degraded and inactivated. Analysis of the digestion products suggested that a minor diversity in their substrate specificities between TLN and BANP affects the sensitivity to the proteinaceous metalloprotease inhibitor, SMPI.

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