ST-1, a Novel Radical Scavenger From Fungus F-124

Abstract

Peroxidase (POD) plays an important role in the biosynthesis of disease-lignin, which protects plants from fungal invasion. A novel POD inhibitor, ST-1 (1), was isolated from a fungus, and its chemical structure was elucidated to be 1, 3-dihydro-4, 5, 6-trihydroxy-1, 3-dimethoxy-7-methylisobenzofuran by a combination of chemical modification and spectroscopic techniques. ST-1 effectively scavenged oxygen radicals and also suppressed the phytoalexin accumulation in kidney bean.