Preparation of 10, 11-Epoxy-carbamazepine and 10, 11-Dihydro-10-hydroxy-carbamazepine by Microbial Epoxidation and Hydroxylation

Abstract

Within a microbial screening two bacterial strains were identified that epoxidize carbamazepine (CBZ) to 10, 11-epoxy-CBZ. Ten strains could hydroxylate 10, 11-dihydro-CBZ to 10, 11-dihydro-10-hydroxy-CBZ. All active organisms belonged to the genus Strep-tomyces. Both reactions were done in a preparative scale using S. violascens ATCC 31560. The culture conditions for the hydroxylation with this strain were improved.