Stimulation of Nerve Growth Factor (NGF) Synthesis by Tryptophan and Its Metabolites in Cultured Mouse Astroglial Cells

Kiwao Nakano; Hiromichi Kondo; Michiko Hattori; Sachiko Tsubouchi; Shoei Furukawa

doi:10.1271/bbb.58.2116

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Stimulation of Nerve Growth Factor (NGF) Synthesis by Tryptophan and Its Metabolites in Cultured Mouse Astroglial Cells

Kiwao Nakano, Hiromichi Kondo, Michiko Hattori, Sachiko Tsubouchi, Shoei Furukawa

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JOURNAL FREE ACCESS

1994 Volume 58 Issue 11 Pages 2116-2117

DOI https://doi.org/10.1271/bbb.58.2116

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Abstract

Effects of L-tryptophan and its metabolites were evaluated on synthesis of nerve growth factor (NGF) in cultured mouse astroglial cells. L-Tryptophan stimulated NGF production in a dose-dependent fashion. Serotonin and quinolinic acid slightly increased NGF synthesis. L-Kynurenine had a marked stimulatory effect on NGF synthesis at a dose of 100μM. In contrast, kynurenic acid had no effect.

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