Inhibition of Cholesterol Absorption by Oxidized Cholesterol in Rats

Abstract

The effects on cholesterol absorption of oxidized cholesterols were studied in lymph-cannulated rats. When a single emulsitied lipid meal containing a tracer amount of [¹⁴C]cholesterol with either 50 mg cholesterol or 50mg oxidized cholesterol mixture was administered intragastrically, the lymphatic absorption of cholesterol for 24h was 33.1±6.3 and 21.7±82.6%, respectively. Moreover, oxidized cholesterols also inhibited the absorption of triolein (85.9±3.2% and 59. 5±18.8%). The observation may be of use since the ingestion of oxidized cholesterols tends to be increasing.