Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Effects of α- and β-Arbutin on Activity of Tyrosinases from Mushroom and Mouse Melanoma
Masataka FunayamaHirokuni ArakawaRyohei YamamotoToyokazu NishinoTakashi ShinSawao Murao
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JOURNAL FREE ACCESS

1995 Volume 59 Issue 1 Pages 143-144

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Abstract

The effects of α- and β-arbutin on the activity of tyrosinases from mushroom and mouse melanoma were examined. α-Arbutin was synthesized from hydroquinone and starch using glucoside synthetase (GSase). β-Arbutin inhibited both tyrosinase activities from mushroom and mouse melanoma. α-Arbutin inhibited only the tyrosinase from mouse melanoma, 10 times as strongly as β-arbutin. The IC50 of α-arbutin was 0.48 mM and its inhibitory mechanism was speculated to be mixed type inhibition, while that of β-arbutin was noncompetitive.

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