Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Continuous and Massive Intake of Chitosan Affects Mineral and Fat-soluble Vitamin Status in Rats Fed on a High-fat Diet
Keiji DeuchiOsamu KanauchiMika ShizukuishiEiichi Kobayashi
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1995 Volume 59 Issue 7 Pages 1211-1216


We investigated the effects of continuous and massive intake of chitosan with sodium ascorbate (AsN) on the mineral and the fat-soluble vitamin status in male Sprague-Dawley rats fed on a high-fat diet. The apparent fat digestibility in the chitosan-receiving group was significantly lower than that in the cellulose- or glucosamine-receiving group. Chitosan feeding for 2 weeks caused a decrease in mineral absorption and bone mineral content, and it was necessary to administer twice the amount of Ca in the AIN-76 formula, which was supplemented with AsN, to prevent such a decrease in the bone mineral content. Moreover, the ingestion of chitosan along with AsN led to a marked and rapid decrease in the serum vitamin E level, while such a loss in vitamin E was not observed for rats given glucosamine monomer instead of chitosan.

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