Conserved Organization of Genes for Biosynthesis of Chlortetracycline in Streptomyces Strains

Tohru Dairi; Tetsuo Nakano; Toru Mizukami; Kazuo Aisaka; Mamoru Hasegawa; Ryoichi Katsumata

doi:10.1271/bbb.59.1360

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Conserved Organization of Genes for Biosynthesis of Chlortetracycline in Streptomyces Strains

Tohru Dairi, Tetsuo Nakano, Toru Mizukami, Kazuo Aisaka, Mamoru Hasegawa, Ryoichi Katsumata

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JOURNAL FREE ACCESS

1995 Volume 59 Issue 7 Pages 1360-1361

DOI https://doi.org/10.1271/bbb.59.1360

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Abstract

By genomic Southern blot analysis, the DNA sequences homologous to the gene cluster responsible for biosynthesis of 6-demethyl-chlortetracycline in Streptomyces aureofaciens NRRL3203 were shown to be highly conserved in independent chlortetracycline- or tetracycline producing Streptomyces strains. By contrast, oxytetracycline-producing Streptomyces strains had no hybridization with the cluster DNA.

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