1995 Volume 59 Issue 8 Pages 1600-1602
Three mutants with lower levels of tryptophan uptake were derived from a tryptophan-producing strain of Corynebacterium glutamicum. They all showed improved production kinetics at the latter half of fermentation and accumulated 10 to 20% more tryptophan than their parent. These results indicate that prevention of amino acid uptake can be a useful strategy to bypass remaining regulatory steps and thereby to increase the yield and productivity in amino acid high-producing strains.
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