Relative Activity of N-(β-D-Glucopyranosyl)nicotinic Acid to Nicotinic Acid as a Niacin Nutrient in Rats and in Lactobacillus plantarum ATCC 8014

Abstract

We investigated the relative activity of N-(β-D-glucopyranosyl)-nicotinic acid to nicotinic acid as a niacin nutrient in rats and in Lactobacillus plantarum ATCC 8014. N-(β-D-Glucopyranosyl)nicotinic acid is a detoxified product or storage form of nicotinic acid that is found in plants. The relative activity of N-(β-D-gluco-pyranosyl)nicotinic acid to nicotinic acid in rats was 1/2.3, 1/2.2, 1/1.0, and 1/1.7 as indices of the body weight gain, food intake, blood NAD content, and the increased urinary excretion of niacin and its metabolites, respectively. N-(β-D-Glucopyranosyl)nicotinic acid had no niacini activity in Lactobacillus plantarum ATCC 8014.