Bone Resorption Inhibitors from Hop Extract

Hiroyasu Tobe; Yoshifumi Muraki; Kazuyuki Kitamura; Osamu Komiyama; Yusuke Sato; Tatsuo Sugioka; Hiromi B. Maruyama; Eriko Matsuda; Masahiro Nagai

doi:10.1271/bbb.61.158

Hiroyasu Tobe, Yoshifumi Muraki, Kazuyuki Kitamura, Osamu Komiyama, Yusuke Sato, Tatsuo Sugioka, Hiromi B. Maruyama, Eriko Matsuda, Masahiro Nagai

Author information

Hiroyasu Tobe
Yoshifumi Muraki
Kazuyuki Kitamura
Osamu Komiyama
Yusuke Sato
Tatsuo Sugioka
Hiromi B. Maruyama
Eriko Matsuda
Masahiro Nagai
Author's Organization：
Pharma Research and Development Division, Drug Discovery Research Laboratories, Hoechst Japan Limited
Pharma Research and Development Division, Drug Discovery Research Laboratories, Hoechst Japan Limited:Corresponding author
Pharma Research and Development Division, Drug Discovery Research Laboratories, Hoechst Japan Limited
Pharma Research and Development Division, Drug Discovery Research Laboratories, Hoechst Japan Limited
Pharma Research and Development Division, Drug Discovery Research Laboratories, Hoechst Japan Limited
Pharma Research and Development Division, Drug Discovery Research Laboratories, Hoechst Japan Limited
Pharma Research and Development Division, Drug Discovery Research Laboratories, Hoechst Japan Limited
Hoshi University, Faculty of Pharmaceutical Sciences
Hoshi University, Faculty of Pharmaceutical Sciences

Keywords: bone resorption inhibitor, hop extract, humulone, xanthohumol

JOURNAL FREE ACCESS

1997 Volume 61 Issue 1 Pages 158-159

DOI https://doi.org/10.1271/bbb.61.158

Details

Abstract

We searched hop extract for active component(s) that inhibited bone resorption in the pit formation assay, and isolated xanthohumol and humulone as active ingredients. Especially humulone had extraordinarily strong inhibitory activity and the IC₅₀ (concentration of 50% inhibition) value was 5.9 x 10^-9 M.

Corresponding author

Register with J-STAGE for free!